CCE_DART aims to incorporate newer and more effective methods to the design, conduct, and analysis of academic clinical trials. The project has been built around Cancer Core Europe (CCE), a network of comprehensive cancer research centers, and the Basket of Baskets Clinical Trial, a modular multi-country investigator-led precision medicine trial.

Cancer Core Europe offers the perfect setting for the implementation of the CCE_DART proposal, as it counts with state-of-the-art platforms for molecular patient selection, a critical mass of patients and a unique infrastructure including bioinformatics and translational research capabilities able to support clinical trials in small patient populations. The framework collaboration integrates standardized prescreening methods (including a 350-genes panel) and common standard operating procedures, contracts and budgets. Its design allows both the development of sponsor-initiated trials and modular investigator-initiated trials, providing flexibility for adding new arms with different molecular alterations.