{"id":4886,"date":"2023-12-01T10:55:21","date_gmt":"2023-12-01T09:55:21","guid":{"rendered":"https:\/\/dart.datariverweb.com\/iEnter?page_id=4886"},"modified":"2024-02-26T17:54:50","modified_gmt":"2024-02-26T16:54:50","slug":"estudio-clinico-bob-y-sus-resultados","status":"publish","type":"page","link":"https:\/\/dart.datariverweb.com\/iEnter?page_id=4886&lang=es","title":{"rendered":"Estudio Cl\u00ecnico Bob y sus resultados"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4886\" class=\"elementor elementor-4886 elementor-4778\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-664f0590 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"664f0590\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-44ef6ac6\" data-id=\"44ef6ac6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1645fa91 elementor-widget elementor-widget-spacer\" data-id=\"1645fa91\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! 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elementor - v3.8.0 - 30-10-2022 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">Estudio Cl\u00ecnico Bob y sus resultados<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-104637b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"104637b\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! 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elementor - v3.8.0 - 30-10-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Como se describe en la secci\u00f3n &#8220;Para saber m\u00e1s&#8221;, el estudio BOB consta de dos fases.<\/p>\n<p>En la primera fase (Parte A, i-Profiler), se analiza el tejido tumoral para evaluar mediante un panel molecular(Parte B, i-Basket).<\/p>\n<p>La segunda fase (Parte B, i-Basket) es el ensayo cl\u00ednico real tipo \u201cbasket&#8221;, para sujetos con alteraciones moleculares seleccionadas en el i-Profiler. Cada m\u00f3dulo se centra en determinada v\u00eda molecular o en determinadas alteraciopnes que le puedan conferir sensibilidad al f\u00e1rmaco del estudio o a la combinaci\u00f3n del f\u00e1rmaco de estudio evaluda en ese m\u00f3dulo\/brazo.<\/p>\n<p>Actualmente, se han activado 3 Brazos, cada uno dedicado a un conjunto espec\u00edfico de mutaciones:<\/p>\n<p>1.<\/p>\n<ul>\n<li>Medicamento: atezolizumab<\/li>\n<li>Modo de administraci\u00f3n: intravenoso<\/li>\n<li>Posolog\u00eda: 1200 mg, una vez cada 3 semanas<\/li>\n<li>N\u00famero de pacientes a reclutar (planificado): 120<\/li>\n<li>Estado de reclutamiento de pacientes: a\u00fan en curso<\/li>\n<\/ul>\n<p>2.<\/p>\n<ul>\n<li>Medicamento: futibatinib<\/li>\n<li>Modo de administraci\u00f3n: oral<\/li>\n<li>Posolog\u00eda: 20 mg, una vez al d\u00eda continuamente en ciclos de 28 d\u00edas<\/li>\n<li>N\u00famero de pacientes a reclutar (planificado): 80<\/li>\n<li>Estado de reclutamiento de pacientes: a\u00fan en curso<\/li>\n<\/ul>\n<p>3.<\/p>\n<ul>\n<li>Medicamento: amivantamab<\/li>\n<li>Modo de administraci\u00f3n: intravenoso<\/li>\n<li>Posolog\u00eda:\n<ul>\n<li>Peso corporal &lt;80 kg: 1050 mg, una vez a la semana en el primer ciclo y cada 2 semanas en ciclos posteriores.<\/li>\n<li>Peso corporal \u226580 kg: 1400 mg, una vez a la semana en el primer ciclo y cada 2 semanas en ciclos posteriores.<\/li>\n<\/ul>\n<\/li>\n<li>N\u00famero de pacientes a reclutar (planificado): 69<\/li>\n<li>Estado de reclutamiento de pacientes: a\u00fan en curso<\/li>\n<\/ul>\n<p>Los 7 centros de investigaci\u00f3n en c\u00e1ncer, pertenecientes a Cancer Core Europe, e involucrados en el proceso de reclutamiento de pacientes son: Gustave Roussy (Francia), German Cancer Research Center &amp; National Center for Tumor Diseases Heidelberg (Alemania), Fondazione IRCCS Istituto Nazionale dei Tumori di Milano (Italia), Netherlands Cancer Institute (Pa\u00edses Bajos), Vall d\u2019Hebron Instituto de Oncolog\u00eda (Espa\u00f1a), Karolinska Institutet (Suecia), Cancer Research UK Cambridge Centre (Reino Unido).<\/p>\n<p>El estudio cl\u00ednico BoB est\u00e1 activo desde diciembre de 2018 y se estima que finalizar\u00e1 en noviembre de 2026 (mayo de 2025 como la fecha asumida de finalizaci\u00f3n del reclutamiento de pacientes).<\/p>\n<p>Para obtener m\u00e1s informaci\u00f3n, puedes visita<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03767075\">https:\/\/clinicaltrials.gov\/study\/NCT03767075<\/a> o ponerte en contacto con tu onc\u00f3logo o el personal cl\u00ednico involucrado en el proceso de tratamiento.<\/p>\n<p><strong><u>Resultados<\/u><\/strong><\/p>\n<p>Content not yet available.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-478546c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"478546c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4bed840\" data-id=\"4bed840\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-773794f elementor-widget elementor-widget-spacer\" data-id=\"773794f\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f4a123d elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f4a123d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-2821e9b\" data-id=\"2821e9b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-68426e1 elementor-widget elementor-widget-text-editor\" data-id=\"68426e1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<\/p>\n<p>El proyecto CCE_DART ha recibido financiaci\u00f3n del programa de investigaci\u00f3n e innovaci\u00f3n Horizonte 2020 de la Uni\u00f3n Europea en virtud del acuerdo de subvenci\u00f3n n\u00ba 965397<\/p><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-5c93775\" data-id=\"5c93775\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6a61c09 elementor-widget elementor-widget-image\" data-id=\"6a61c09\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.8.0 - 30-10-2022 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"172\" height=\"48\" src=\"https:\/\/dart.datariverweb.com\/iEnter\/wp-content\/uploads\/2020\/12\/logo-eu-en.svg\" class=\"attachment-large size-large\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Estudio Cl\u00ecnico Bob y sus resultados Como se describe en la secci\u00f3n &#8220;Para saber m\u00e1s&#8221;, el estudio BOB consta de dos fases. En la primera fase (Parte A, i-Profiler), se analiza el tejido tumoral para evaluar mediante un panel molecular(Parte B, i-Basket). La segunda fase (Parte B, i-Basket) es el ensayo cl\u00ednico real tipo \u201cbasket&#8221;, para sujetos con alteraciones moleculares seleccionadas en el i-Profiler. Cada m\u00f3dulo se centra en determinada v\u00eda molecular o en determinadas alteraciopnes que le puedan conferir sensibilidad al f\u00e1rmaco del estudio o a la combinaci\u00f3n del f\u00e1rmaco de estudio evaluda en ese m\u00f3dulo\/brazo. Actualmente, se han\u2026<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"class_list":["post-4886","page","type-page","status-publish","hentry"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":5}},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=\/wp\/v2\/pages\/4886","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4886"}],"version-history":[{"count":3,"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=\/wp\/v2\/pages\/4886\/revisions"}],"predecessor-version":[{"id":4901,"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=\/wp\/v2\/pages\/4886\/revisions\/4901"}],"wp:attachment":[{"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4886"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}