{"id":4778,"date":"2023-12-01T10:55:21","date_gmt":"2023-12-01T09:55:21","guid":{"rendered":"https:\/\/dart.datariverweb.com\/iEnter?page_id=4778"},"modified":"2023-12-04T10:06:31","modified_gmt":"2023-12-04T09:06:31","slug":"bor-results-2","status":"publish","type":"page","link":"https:\/\/dart.datariverweb.com\/iEnter?page_id=4778","title":{"rendered":"BoB Trial and its results"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4778\" class=\"elementor elementor-4778\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-664f0590 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"664f0590\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-44ef6ac6\" data-id=\"44ef6ac6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1645fa91 elementor-widget elementor-widget-spacer\" data-id=\"1645fa91\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.8.0 - 30-10-2022 *\/\n.elementor-column 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class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc7ee20 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"bc7ee20\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.8.0 - 30-10-2022 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">BoB Trial and its results<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-104637b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"104637b\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.8.0 - 30-10-2022 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#2c2c2c;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:-webkit-box;display:-ms-flexbox;display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);-ms-flex-negative:0;flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider .elementor-divider-separator{display:-webkit-box;display:-ms-flexbox;display:flex;margin:0;direction:ltr}.elementor-widget-divider--view-line_icon .elementor-divider-separator,.elementor-widget-divider--view-line_text .elementor-divider-separator{-webkit-box-align:center;-ms-flex-align:center;align-items:center}.elementor-widget-divider--view-line_icon .elementor-divider-separator:after,.elementor-widget-divider--view-line_icon .elementor-divider-separator:before,.elementor-widget-divider--view-line_text .elementor-divider-separator:after,.elementor-widget-divider--view-line_text 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.elementor-divider__element{margin-right:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%)}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c5e3002 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c5e3002\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0c568ed\" data-id=\"0c568ed\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3cb9e44 elementor-widget elementor-widget-text-editor\" data-id=\"3cb9e44\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.8.0 - 30-10-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>As described in the \u201cTo know More\u201d section, there are two phases in the BoB trial.<\/p><p>In the first phase (Part A, i-Profiler), tumor tissue is analyzed to assess whether there are genetic mutations that could be a target for the drug that will be administered in the second phase (Part B, i-Basket).<\/p><p>The second phase is the actual clinical trial, in which all patients with a certain mutation are treated with the same drug.<\/p><p>Currently 3 studies have been activated, each dedicated to a specific set of mutations:<\/p><p>1.<\/p><ul><li>Drug: atezolizumab<\/li><li>Mode of administration: intravenous<\/li><li>Posology: 1200 mg, once every 3 weeks<\/li><li>Number of patients to be recruited (planned): 120<\/li><li>Patients enrolment status: still ongoing<\/li><\/ul><p>2.<\/p><ul><li>Drug: futibatinib<\/li><li>Mode of administration: orally<\/li><li>Posology: 20 mg, once daily continuously in 28-day cycles<\/li><li>Number of patients to be recruited (planned): 80<\/li><li>Patients enrolment status: still ongoing<\/li><\/ul><p>3.<\/p><ul><li>Drug: amivantamab<\/li><li>Mode of administration: intravenous<\/li><li>Posology:<ul><li>body weight &lt;80Kg: 1050 mg, once a week in the first cycle and every 2 weeks in subsequent cycles.<\/li><li>body weight \u226580Kg: 1400 mg, once a week in the first cycle and every 2 weeks in subsequent cycles.<\/li><\/ul><\/li><li>Number of patients to be recruited (planned): 69<\/li><li>Patient enrolment status: still ongoing<\/li><\/ul><p>The 7 cancer centers, belonging to Cancer Core Europe, and involved in the patient recruitment process are: Gustave Roussy (France), German Cancer Research Center &amp; National Center for Tumor Diseases Heidelberg (Germany), Fondazione IRCCS Istituto Nazionale dei Tumori di Milano (Italy), Netherlands Cancer Institute (Netherlands), Vall d&#8217;Hebron Institute of Oncology (Spain), Karolinska Institutet (Sweden), Cancer Research UK Cambridge Centre (United Kingdom).<\/p><p>The BoB trial is active from December 2018 and is estimated to end by November 2026 (May 2025 as the assumed end date of patient recruitment).<\/p><p>For more information, you can visit <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03767075\">https:\/\/clinicaltrials.gov\/study\/NCT03767075<\/a> or contact your oncologist, or the clinical staff involved in the treatment process.<\/p><p><strong><u>Results<\/u><\/strong><\/p><p>Content not yet available.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-478546c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"478546c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4bed840\" data-id=\"4bed840\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-773794f elementor-widget elementor-widget-spacer\" data-id=\"773794f\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f4a123d elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f4a123d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-2821e9b\" data-id=\"2821e9b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-68426e1 elementor-widget elementor-widget-text-editor\" data-id=\"68426e1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u00a0<\/p><p>The CCE_DART project has received funding from the European Union&#8217;s Horizon 2020 research and innovation programme under grant agreement No 965397<\/p><p>\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-5c93775\" data-id=\"5c93775\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6a61c09 elementor-widget elementor-widget-image\" data-id=\"6a61c09\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.8.0 - 30-10-2022 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"172\" height=\"48\" src=\"https:\/\/dart.datariverweb.com\/iEnter\/wp-content\/uploads\/2020\/12\/logo-eu-en.svg\" class=\"attachment-large size-large\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>BoB Trial and its results As described in the \u201cTo know More\u201d section, there are two phases in the BoB trial. In the first phase (Part A, i-Profiler), tumor tissue is analyzed to assess whether there are genetic mutations that could be a target for the drug that will be administered in the second phase (Part B, i-Basket). The second phase is the actual clinical trial, in which all patients with a certain mutation are treated with the same drug. Currently 3 studies have been activated, each dedicated to a specific set of mutations: 1. Drug: atezolizumab Mode of administration:\u2026<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"class_list":["post-4778","page","type-page","status-publish","hentry"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":5}},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=\/wp\/v2\/pages\/4778","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4778"}],"version-history":[{"count":17,"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=\/wp\/v2\/pages\/4778\/revisions"}],"predecessor-version":[{"id":4878,"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=\/wp\/v2\/pages\/4778\/revisions\/4878"}],"wp:attachment":[{"href":"https:\/\/dart.datariverweb.com\/iEnter\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4778"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}